Intranasal Drug Delivery (Systemic)

ZEOx1™ and ZEOx2™ delivery systems are designed for non-invasive systemic delivery of drugs, biopharmaceuticals, biologics or botanicals via the nasal route. Intranasal delivery applications include pain management, migraine crisis, hormone replacement, seizures, anaphylaxis, emesis, anxiety & depression, hypoglycemia & diabetes, cannabinoids, proteins & peptides, vaccines, anti-virals and biomedical countermeasures.  

ZEOx1™ and ZEOx2™ intranasal drug delivery systems employ a patient-centric design to facilitate self-administration, ease of use and consistent precise delivery. ZEOx1 nasal delivery systems are designed for aqueous or non-aqueous liquid formulations and can be configured to dispense a targeted dose ranging from 20 µL to 110 µL per dose.  ZEOx2™ nasal delivery systems can be configured for powder delivery, or to auto-reconstitute a dry powder formulation to a liquid, or auto-combine two separately packaged liquid formulations at the time of dosing by the patient or caregiver.  ZEOx1 and ZEOx2 nasal delivery systems are available in mono-dose disposable, mono-dose cartridge reloadable and multi-dose dispenser configurations.

ZEOx1 OrionMRQ™ mono-dose nasal delivery system

OrionMRQ unit dose reloadable nasal cartridge

ZEOx1 OrionMRS™ mono-dose reloadable nasal delivery system (liquid)

ZEOx1 OrionSDX™ mono-dose disposable nasal delivery system (liquid)

ZEOx2 CygnusSDX™ nasal powder delivery system

The CygnusSDX is a single dose, disposable, precision metered dose nasal dispenser for powder formulations.  The device is ultra-compact and is configured for immediate emergency use by the patient, caregive or first responder.  The ultra-compact size makes it easy to carry and enable space efficient storage for strategic stockpiling of large quantities of ready to use countermeasures.

Key performance features of our ZEOx1™ and ZEOx2™ intranasal drug delivery systems include:

• Liquid, powder, reconstituted powder to liquid dispenser configurations
• Mono-dose disposable and mono-dose reloadable configurations available
• Intuitive design and operation to facilitate first use
• Compact dispenser footprint for ease of carry in a purse or pocket
• Side actuation dispenser device for ease of use
• No device priming required
• Mechanically actuated dispense eliminates the need for battery power
• Safety lock to prevent inadvertent dispense during handling, storage or transport
• Intuitive dispenser operation facilitates first time use
• Dose counter
• Orientation independent device actuation
• Configurable spray plume
• Metal free fluid delivery path
• Non-sterile and aseptic packaging for preservative free formulations
• Sterility assurance throughout the “in use” product life and in the dispensed dose
• Exceptional primary container barrier properties for shelf stability
• Tamper resistant packaging
• Commercially scalable, cost efficient design for manufacturing

Key performance features of our ZEOx1™ and ZEOx2™ intranasal drug delivery systems include:

• Liquid, powder, reconstituted powder to liquid dispenser configurations
• Mono-dose disposable and mono-dose reloadable configurations available
• Intuitive design and operation to facilitate first use
• Compact dispenser footprint for ease of carry in a purse or pocket
• Side actuation dispenser device for ease of use
• No device priming required

• Mechanically actuated dispense eliminates the need for battery power

• Safety lock to prevent inadvertent dispense during handling, storage or transport

• Intuitive dispenser operation facilitates first time use

• Dose counter
• Orientation independent device actuation
• Configurable spray plume
• Metal free fluid delivery path
• Non-sterile and aseptic packaging for preservative free formulations
• Sterility assurance throughout the “in use” product life and in the dispensed dose
• Exceptional primary container barrier properties for shelf stability
• Tamper resistant packaging
• Commercially scalable, cost efficient design for manufacturing