Intranasal Drug Delivery (Systemic)

ZEOx1™ and ZEOx2™ delivery systems are designed for non-invasive systemic delivery of drugs, biopharmaceuticals, biologics or botanicals via the nasal route. Intranasal delivery applications include pain management, migraine crisis, hormone replacement, seizures, anaphylaxis, emesis, anxiety & depression, hypoglycemia & diabetes, cannabinoids, proteins & peptides, vaccines, anti-virals and biomedical countermeasures.  

ZEOx1™ and ZEOx2™ intranasal drug delivery systems employ a patient-centric design to facilitate self-administration, ease of use and consistent precise delivery. ZEOx1 nasal delivery systems are designed for aqueous or non-aqueous liquid formulations and can be configured to dispense a targeted dose ranging from 20 µL to 110 µL per dose.  ZEOx2™ nasal delivery systems can be configured for powder delivery, or to auto-reconstitute a dry powder formulation to a liquid, or auto-combine two separately packaged liquid formulations at the time of dosing by the patient or caregiver.  ZEOx1 and ZEOx2 nasal delivery systems are available in mono-dose disposable, mono-dose cartridge reloadable and multi-dose dispenser configurations.

ZEOx1 OrionSD™ mono-dose disposable nasal delivery system (liquid)

ZEOx1 OrionSR™ mono-dose reloadable nasal delivery system (liquid)

ZEOx2 CygnusSD™ & CygnusSR™ nasal delivery system (powder) available in
mono-dose disposable and reloadable configurations.

Key performance features of our ZEOx1™ and ZEOx2™ intranasal drug delivery systems include:

  • Liquid, powder, reconstituted powder to liquid dispenser configurations
  • Mono-dose disposable and mono-dose reloadable configurations available
  • Intuitive design and operation to facilitate first use
  • Compact dispenser footprint for ease of carry in a purse or pocket
  • Side actuation dispenser device for ease of use
  • No device priming required
  • Mechanically actuated dispense eliminates the need for battery power

  • Safety lock to prevent inadvertent dispense during handling, storage or transport

  • Intuitive dispenser operation facilitates first time use

  • Dose counter
  • Orientation independent device actuation
  • Configurable spray plume
  • Metal free fluid delivery path
  • Non-sterile and aseptic packaging for preservative free formulations
  • Sterility assurance throughout the “in use” product life and in the dispensed dose
  • Exceptional primary container barrier properties for shelf stability
  • Tamper resistant packaging
  • Commercially scalable, cost efficient design for manufacturing

Key performance features of our ZEOx1™ and ZEOx2™ intranasal drug delivery systems include:

  • Liquid, powder, reconstituted powder to liquid dispenser configurations
  • Mono-dose disposable and mono-dose reloadable configurations available
  • Intuitive design and operation to facilitate first use
  • Compact dispenser footprint for ease of carry in a purse or pocket
  • Side actuation dispenser device for ease of use
  • No device priming required
  • Mechanically actuated dispense eliminates the need for battery power

  • Safety lock to prevent inadvertent dispense during handling, storage or transport

  • Intuitive dispenser operation facilitates first time use

  • Dose counter
  • Orientation independent device actuation
  • Configurable spray plume
  • Metal free fluid delivery path
  • Non-sterile and aseptic packaging for preservative free formulations
  • Sterility assurance throughout the “in use” product life and in the dispensed dose
  • Exceptional primary container barrier properties for shelf stability
  • Tamper resistant packaging
  • Commercially scalable, cost efficient design for manufacturing

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