Nose to Brain Drug Delivery Systems

Non-invasive intranasal delivery of small molecules, proteins, peptides and monoclonal antibodies exploits the olfactory and trigeminal neuronal pathways to bypass the Blood Brain Barrier and deliver the therapeutic directly to the brain. Intranasal administration of therapeutics for the treatment of CNS and neurodegenerative disorders such as brain tumors, HIV encephalopathy, epilepsy, stroke, Parkinson’s, Huntington, Alzheimer’s and Traumatic Brain Injury offer compelling benefits for the patient. Zeteo optimized nose to brain drug delivery systems are designed to facilitate intracranial administration for both caregiver and the patient, minimize systemic exposure and enable rapid CNS delivery of the therapeutic.

ZEOx1 OrionSD™ mono-dose disposable nasal delivery system (liquid)

ZEOx1 OrionSR™ mono-dose reloadable nasal delivery system (liquid)

ZEOx2 CygnusSD™ & CygnusSR™ nasal delivery system (powder) available in
mono-dose disposable and reloadable configurations.

Key performance features of our ZEOx1™ and ZEOx2™ nose to brain drug delivery systems include:

  • Liquid, powder, reconstituted powder to liquid or liquid/liquid recombination dispenser configurations
  • Mono-dose disposable and mono-dose reloadable configurations available
  • Precise dosing that can be calibrated to a specified delivered dose
  • Intuitive design and operation to facilitate first use
  • Compact dispenser footprint for ease of carry in a purse or pocket
  • Side actuation dispenser device for ease of use
  • Mechanically actuated dispense eliminates the need for battery power

  • Safety lock to prevent inadvertent dispense during handling, storage or transport

  • Intuitive dispenser operation facilitates first time use

  • No device priming required
  • Dose counter
  • Orientation independent device actuation
  • Configurable spray plume
  • Metal free fluid delivery path
  • Non-sterile, terminally sterilized or sterile packaging for preservative free formulations
  • Sterility assurance throughout the “in use” product life and in the dispensed dose
  • Exceptional primary container barrier properties for long term shelf stability
  • Tamper resistant packaging
  • Commercially scalable, cost efficient design for manufacturing

Key performance features of our ZEOx1™ and ZEOx2™ nose to brain drug delivery systems include:

  • Liquid, powder, reconstituted powder to liquid or liquid/liquid recombination dispenser configurations
  • Mono-dose disposable and mono-dose reloadable configurations available
  • Precise dosing that can be calibrated to a specified delivered dose
  • Intuitive design and operation to facilitate first use
  • Compact dispenser footprint for ease of carry in a purse or pocket
  • Side actuation dispenser device for ease of use
  • Mechanically actuated dispense eliminates the need for battery power

  • Safety lock to prevent inadvertent dispense during handling, storage or transport

  • Intuitive dispenser operation facilitates first time use

  • No device priming required
  • Dose counter
  • Orientation independent device actuation
  • Configurable spray plume
  • Metal free fluid delivery path
  • Non-sterile, terminally sterilized or sterile packaging for preservative free formulations
  • Sterility assurance throughout the “in use” product life and in the dispensed dose
  • Exceptional primary container barrier properties for long term shelf stability
  • Tamper resistant packaging
  • Commercially scalable, cost efficient design for manufacturing

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