Nose to Brain Drug Delivery Devices

Non-invasive intranasal delivery of small molecules, proteins, peptides and monoclonal antibodies exploits the olfactory and trigeminal neuronal pathways to bypass the Blood Brain Barrier and deliver the therapeutic directly to the brain. Intranasal administration of therapeutics for the treatment of CNS and neurodegenerative disorders such as brain tumors, HIV encephalopathy, epilepsy, stroke, Parkinson’s, Huntington, Alzheimer’s and Traumatic Brain Injury offer compelling benefits for the patient. Zeteo optimized nose to brain drug delivery systems are designed to facilitate intracranial administration for both caregiver and the patient, minimize systemic exposure and enable rapid CNS delivery of the therapeutic.

ZTECH-L™ OrionMRQ™ mono-dose nasal delivery system

OrionMRQ unit dose reloadable nasal cartridge

ZTECH-L™ OrionMRS™ mono-dose reloadable nasal delivery system (liquid)

ZTECH-L™ OrionSDX™ mono-dose disposable nasal delivery system (liquid)

ZTECH-P™ CygnusSDX™ nasal powder delivery system

The CygnusSDX is a single dose, disposable, precision metered dose nasal dispenser for powder formulations.  The device is ultra-compact and is configured for immediate emergency use by the patient, caregive or first responder.  The ultra-compact size makes it easy to carry and enable space efficient storage for strategic stockpiling of large quantities of ready to use countermeasures.

Key performance features of our ZTECH-L™ and ZTECH-P™ intranasal drug delivery systems include:

• Liquid, powder, reconstituted powder to liquid dispenser configurations
• Mono-dose disposable and mono-dose reloadable configurations available
• Intuitive design and operation to facilitate first use
• Compact dispenser footprint for ease of carry in a purse or pocket
• Side actuation dispenser device for ease of use
• No device priming required
• Mechanically actuated dispense eliminates the need for battery power
• Safety lock to prevent inadvertent dispense during handling, storage or transport
• Intuitive dispenser operation facilitates first time use
• Dose counter
• Orientation independent device actuation
• Configurable spray plume
• Metal free fluid delivery path
• Non-sterile and aseptic packaging for preservative free formulations
• Sterility assurance throughout the “in use” product life and in the dispensed dose
• Exceptional primary container barrier properties for shelf stability
• Tamper resistant packaging
• Commercially scalable, cost efficient design for manufacturing

Key performance features of our ZTECH-L™ and ZTECH-P™ intranasal drug delivery systems include:

• Liquid, powder, reconstituted powder to liquid dispenser configurations
• Mono-dose disposable and mono-dose reloadable configurations available
• Intuitive design and operation to facilitate first use
• Compact dispenser footprint for ease of carry in a purse or pocket
• Side actuation dispenser device for ease of use
• No device priming required

• Mechanically actuated dispense eliminates the need for battery power

• Safety lock to prevent inadvertent dispense during handling, storage or transport

• Intuitive dispenser operation facilitates first time use

• Dose counter
• Orientation independent device actuation
• Configurable spray plume
• Metal free fluid delivery path
• Non-sterile and aseptic packaging for preservative free formulations
• Sterility assurance throughout the “in use” product life and in the dispensed dose
• Exceptional primary container barrier properties for shelf stability
• Tamper resistant packaging
• Commercially scalable, cost efficient design for manufacturing